Cut your finger or graze your knee and your blood will quickly clot to plug the hole. Nature's healing process begins when tiny blood cells – platelets – are prompted to clump together by a protein called collagen. At the site of an injury, blood leaks out of ruptured blood vessels and clots as the platelets come into contact with collagen present inside the vessel walls. However, these wound healers can also form clots in diseased vessels, sometimes causing heart attacks or strokes. By studying how platelets are formed and controlled in our bodies, scientists hope to find new ways of preventing or treating blood clots. Platelets are created in bone marrow and we see them here sprouting from the surface of their giant parent cells – megakaryocytes (a fluorescent stain highlights cell proteins as bright specks).
BPoD stands for Biomedical Picture of the Day. Managed by the MRC London Institute of Medical Sciences the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.
BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.