Medical Research Council - Clinical Services Centre

Cell Managers
25 April 2012

Cell Managers

Stem cells, with the potential to become almost any cell type, can regenerate organs. Their fate is carefully orchestrated by transcription factors, cell ‘managers’ which turn on production of whole groups of proteins simultaneously. Similarly, cancer stem cells can regenerate the cancer and often hijack and misuse the same factors. Slug and Sox9 are two of these ‘managers’ in breast stem cells. These powerful molecules must be kept in check as they can help cancers grow. Researchers found that a short burst of Slug and Sox9 together in breast cancer cells in mice causes new cancers to grow easily in the mouse lung (lower panels). Cancer cells are dyed bright orange (left) and are also seen as the dark pink mass in the tissue on the right. This is dangerous cooperation: neither Sox9 alone (upper panels) nor Slug alone has this effect.

Written by Claire Worrall

Search The Archive

Submit An Image

What is BPoD?

BPoD stands for Biomedical Picture of the Day. Managed by the MRC Clinical Sciences Centre the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

Read More

Advertise with BPoD

We are currently offering no-fee advertising opportunities for scientific journals, which provide biomedical images for publication. If you are a journal editor, and would like to be considered for inclusion on our website, please get in touch with the Editor.

More Information