Medical Research Council - Clinical Services Centre

Sparking Memory Loss
21 May 2012

Sparking Memory Loss

Our brain is a treasure trove of memories that form as billions of tiny electrical signals fire off between nerve cells (neurons). Everyday experiences create patterns of signals that vary in type and strength. But, with the onset of Alzheimer’s disease these patterns are disrupted so that treasured memories disappear and new ones are not easily stored. The decline is triggered when two proteins in the brain, called tau and beta amyloid, clump together, and brain cells called astrocytes (here dyed red) accumulate. These tangles multiply, killing vital neurons (shown in blue) as they spread. Scientists have discovered that it’s a highly toxic version of beta-amyloid (shown in green) that ignites this cascade, and escalates spread of disease through the brain. The race is now on to find medicines that can extinguish this spark and protect more memories.

Written by Caroline Cross

Search The Archive

Submit An Image

What is BPoD?

BPoD stands for Biomedical Picture of the Day. Managed by the MRC Clinical Sciences Centre the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

Read More

Advertise with BPoD

We are currently offering no-fee advertising opportunities for scientific journals, which provide biomedical images for publication. If you are a journal editor, and would like to be considered for inclusion on our website, please get in touch with the Editor.

More Information