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Early Warning
14 June 2012

Early Warning

During Alzheimer’s disease, a substance called beta amyloid clumps together in the brain forming plaques, which block the circuitry. These changes in the brain often begin long before patients become confused and forgetful. Over a century since its first description by German psychiatrist Alois Alzheimer – born this day in 1864 – scientists are striving to improve early diagnosis. Pictured are brain scans from elderly individuals given a radioactive tag that homes to beta amyloid. In healthy brains (left), there is virtually none (blue). But in full-blown Alzheimer's (right), a high density of plaques light up in orange and red. Some individuals (middle) don't yet display any outward signs of dementia, but an increase in green reveals a worrying accumulation of beta amyloid. Earlier discovery of Alzheimer's could mean patients will get more benefit from drugs that delay its progression.

Written by Emma Stoye

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BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

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