The fungus pictured will be familiar to most women, if not by its scientific name, Candida albicans, then by its more common moniker, thrush. This little organism commonly causes vaginal infections. But it can also affect the mouth, especially in babies, elderly folk and the immunologically compromised such as people with HIV. Scientists have recently identified a crucial protein in the fungus that serves two opposing functions in such oral infections. It enables Candida to control the acidity of its environment, allowing fungal colonies to form the halo of hyphae (shown in white) necessary for penetrating the lining of the mouth. However, the protein also makes the fungus more susceptible to a natural salivary antiseptic, which in healthy people helps prevent infections from occurring in the first place.
Written by Ruth Williams
BPoD stands for Biomedical Picture of the Day. Managed by the MRC London Institute of Medical Sciences (the new name for the MRC Clinical Sciences Centre) the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.