Medical Research Council - Clinical Services Centre

Intolerant Gut
30 June 2012

Intolerant Gut

Coeliac disease is a chronic autoimmune condition that runs in families and causes diarrhoea, weight loss and abdominal pain. To control symptoms, a gluten-free diet is a must, because it’s gluten, found in wheat, rye and barley, that kick starts the rogue immune response that leads to disease. This ultrathin section of gut taken from a patient shows two important hallmarks of disease. Firstly, shortened finger-like protrusions (villi) in the gut wall make absorbing nutrients difficult. And secondly, an abundance of immune cells called plasma cells (fluorescing yellow) that churn out a maverick antibody (tagged in green) which locks on to the body’s own gluten-digesting enzymes. It’s these autoantibodies and the plasma cells that produce them that interest scientists. Being able to follow their fate in the coeliac gut will help in understanding just how they contribute to disease.

Written by Caroline Cross

Search The Archive

Submit An Image

What is BPoD?

BPoD stands for Biomedical Picture of the Day. Managed by the MRC Clinical Sciences Centre the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

Read More

Advertise with BPoD

We are currently offering no-fee advertising opportunities for scientific journals, which provide biomedical images for publication. If you are a journal editor, and would like to be considered for inclusion on our website, please get in touch with the Editor.

More Information