Medical Research Council - Clinical Services Centre

Tube Lines
06 July 2012

Tube Lines

Our blood vessels are built along tubes of epithelial cells. Specific proteins inside these cells control the growth of the tube as it extends. Air pipes of the fruit fly, Drosophila, grow in a very similar manner to human blood vessels. Here we see epithelial cells expressing differently-coloured fluorescent proteins in the airways of two different flies. The top image shows epithelial cells spreading evenly from left to right along the air pipe (white line). But in a fly lacking a protein called Src42A (bottom image) cells are stretching away from the tube and bunching together. As similar proteins are at work in both Drosophila and human organs, fly studies often provide vital clues to aid drug design, in this case to prevent the malformation of blood vessels in conditions like polycystic kidney disease.

Written by John Ankers

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