Fertilisation is arguably the most important point in our life. Egg and sperm unite pairing together one half of their chromosomes. Both cells have to lose half this genetic information to facilitate the process. Researchers can track the carefully orchestrated sequence of events in a mouse egg by injecting beads (shown in blue) that mimic the DNA. For the all-important separation step the DNA strands must be precisely positioned in the outer reaches of the cell (right). Long, spindle-like proteins (green), tease chromosomes apart inside an awning of sorts at the cell surface. The proteins then rotate leaving half of the DNA in the awning. Other proteins (here coloured red) encourage the awning to break away with the doomed strands. If the chromosomes are wrongly positioned (left and middle), separation begins, but ultimately stalls before they can be extruded.
BPoD stands for Biomedical Picture of the Day. Managed by the MRC London Institute of Medical Sciences the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.
BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.