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Sticking Together
12 March 2013

Sticking Together

Ever been defeated by a particularly tricky bit of flat-pack furniture? Even our cells struggle with DIY sometimes. Within a dividing cell, matching pairs of chromosomes must join up to exchange sections of DNA. This is a delicate process, and if the chromosomes fail to join or separate properly, new cells can end up with serious genetic abnormalities. Some complications are caused by structural faults in a molecular ‘velcro’ called cohesin, which holds the two chromosomes together. The chromosome pairs pictured come from dividing egg cells from mice lacking part of cohesin. In each case complete pairing has been disrupted: by a ‘fork’ (top left) ‘bubbles’ (top right and bottom left) or by failure to join altogether (bottom right). Knowing the crucial role of cohesin is a step towards understanding why some pregnancies fail in the early stages, as egg cells with chromosomal defects rarely survive for long after fertilisation.

Written by Emma Stoye

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BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

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