Medical Research Council - London Institute of Medical Sciences

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Biological Clock
24 December 2015

Biological Clock

Jobs with unsocial working hours should come with a serious health warning as nightshift workers face statistically higher risks of heart disease, diabetes, depression, and sleeping difficulties. Humans aren’t nocturnal and disruptions to our circadian rhythm, which regulates the cycle of sleep and wakefulness, can be debilitating. Anyone who’s experienced jetlag will confirm that our stubborn body clocks make us suffer when we try to shoehorn them into new time zones. It’s been known since the 1970s that a part of the brain called the suprachiasmatic nucleus (SCN) – bright spots middle bottom in this cross-section from a mouse – controls our sleep cycle. But what hasn’t been known until now is that the cycle could all be due to a single protein found in the SCN, called neuromedin, that brain cells use to communicate. The discovery gives scientists a new target to aim for when developing future treatments for sleep disorders.

Written by Tristan Farrow

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