Whether providing furry stress relief, sniffing out signs of hypoglycaemia or simply getting us outside for a walk, dogs already do a great deal for our health. Yet they could also be key to a better understanding of a devastating type of brain tumour, known as glioma, or glioblastoma in its most common and severe form. Arising from astrocytes, which form supportive tissues in the brain, malignant glioblastoma cells (pictured stained orange) occur in dogs as well as in humans, with some broad-headed, flat-nosed breeds like boxers especially at risk. By comparing the genomes of healthy and diseased dogs from 25 different breeds, scientists recently identified three genes associated with canine glioblastoma. These sequences also have human equivalents, which might similarly be linked to brain tumours in human patients. So far, one of the genes has been shown to have reduced activity in cancerous cells, a promising start that warrants further research.
BPoD stands for Biomedical Picture of the Day. Managed by the MRC London Institute of Medical Sciences the website aims to engage everyone, young and old, in the wonders of biomedicine. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.
BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.