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Remote Control
28 June 2017

Remote Control

Patients with certain neurological disorders can achieve relief from their symptoms when appropriate parts of their brains are therapeutically activated. One approach – deep brain stimulation – is as invasive as it sounds, requiring patients to have holes drilled in their skulls and electrodes inserted. An alternative approach – transcranial magnetic stimulation – is entirely non-invasive, yet can only reach the brain’s outer-most layers, thus limiting the conditions it can treat. A new technique currently under development called temporally interfering (TI) stimulation may soon offer the best of both – deep brain stimulation without the surgery. The technique uses two ultrahigh electrical frequencies, which alone don't excite brain cells, passing straight through, but, when combined at a desired target location, interfere with each other and create a low-frequency signal to which neurons respond. Indeed, the image shows TI-induced activation (bright green) of neurons within a mouse’s hippocampus without stimulation of the surrounding brain.

Written by Ruth Williams

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BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

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