BPoD has moved!

BPoD has recently changed our domain name - we can now be found at bpod.org.uk

Please update your bookmarks!

Now in our 13th year of bringing you beautiful imagery from biomedical science every day

Search the archive of over 4000 images

Two on the Alzheimer's Plaque Protein - II Seeking the Source

Finding out more about the origins of amyloid, the protein that forms plaques in the brains of Alzheimer's sufferers

03 October 2021

Seeking the Source

One of the key biological hallmarks of Alzheimer’s disease is the presence of clumps of amyloid molecules in the brain, known as plaques. For many years, researchers have focused on figuring out why amyloid plaques form and how to get rid of them, yet these efforts haven’t led to effective treatments for what is currently an incurable condition. One issue is that amyloid is not only made in the brain but elsewhere in the body too, so it has been hard to figure out where it’s coming from. Researchers have recently managed to disentangle the two sources by using genetically engineered mice that make mouse amyloid in the brain and human amyloid in the liver. The human liver amyloid could still get into the brain (highlighted in red in these brains scans), triggering changes typically seen in Alzheimer’s disease and challenging our understanding of how the disease starts and progresses.

Written by Kat Arney

Search The Archive

Submit An Image

Follow on Tumblr

Follow on Instagram

What is BPoD?

BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

Read More

BPoD is also available in Catalan at www.bpod.cat with translations by the University of Valencia.