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Nervous Eating

DiGeorge syndrome gene mutation results in disrupted communication between cell types

13 August 2022

Nervous Eating

Healthy development relies on countless collaborations between contrasting cells, each meeting at just the right moment like soulmates on a dance floor. One such rendezvous occurs early in the development of the nerves that underlie facial movement and feeling, between neural crest and placode cells – the precursors of pain-sensing neurons and mechanosensory neurons, which fine-tune behaviour by sensing and responding to movement. Genetic mutations that disrupt this coupling are linked to DiGeorge syndrome in children, which causes facial abnormalities and difficulties suckling and swallowing. Researchers examined the developing cranial nerves of mice (pictured) with the mutation and found communication between the cell types, rather than physical proximity, was disrupted, and that neural crest cells (highlighted in green) developed into pain-sensing neurons (red) too soon, upsetting the healthy balance. Deciphering the molecular details of the crosstalk is the next step in attempts to restore the broken communication and one day change lives.

Written by Anthony Lewis

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BPoD stands for Biomedical Picture of the Day. Managed by the MRC Laboratory of Medical Sciences until Jul 2023, it is now run independently by a dedicated team of scientists and writers. The website aims to engage everyone, young and old, in the wonders of biology, and its influence on medicine. The ever-growing archive of more than 4000 research images documents over a decade of progress. Explore the collection and see what you discover. Images are kindly provided for inclusion on this website through the generosity of scientists across the globe.

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