21 July 2013
A Risky Map
Humans have migrated across the globe for more than 100,000 years, evolving in response to the changing environment. This history of adaptation is written in our genes, with different populations carrying genetic variations affecting everything from skin colour to disease risk. These maps show how genes linked to the risk of two diseases – type 2 diabetes and biliary liver cirrhosis (a type of autoimmune disease) – vary across the world. People with gene variations putting them at the greatest risk are marked by red spots, those with a middling risk are yellow and the lowest risk are green. It shows that the risk of type 2 diabetes has gone down as people migrated out of Africa into Asia and America, while their risk of this form of liver cirrhosis has gone up. Tracking these global patterns helps researchers understand how our genes interact with our environment and lifestyle to cause disease.
Written by
- Atul Butte and Erik Corona
- Stanford University School of Medicine, USA
- Originally published under a Creative Commons Attribution license
- Published in PLoS Genet 9(5): e1003447
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